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Knockdown of KCNQ1OT1 suppressed CRC cell proliferation.
(a) The expression of KCNQ1OT1 was silenced in DLD1 and SW480 cells by transfecting with specific shRNAs. The optimal transfection efficiency was obtained after 48 h. (b,c) MTT assay disclosed that the proliferative ability of DLD1 and SW480 cells which were transfected with KCNQ1OT1-specific shRNAs was reduced. **P < 0.01 vs. control group.
