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ZEB1 was upregulated by KCNQ1OT1 in CRC cells.
(a) The levels of ZEB1 in CRC cells and normal cells were measured by qRT-PCR. (b) The correlation between ZEB1 and KCNQ1OT1 was analyzed. (c,d) The mRNA and protein levels of ZEB1 in response to the knockdown of KCNQ1OT1 were measured by qRT-PCR and western blot. (e) Luciferase reporter assays were utilized to determine the effect of KCNQ1OT1 on the promoter activity of ZEB1. N.S: no significant, **P < 0.01 vs. control group.
