| Component | Amount |
| Milli-Q water | 44 μL |
| 10× NEBuffer 2 | 10 μL |
| SAM (32 mM) | 2 μL |
| Unmethylated lambda DNA (450 μg/ mL) | 40 μL |
| SssI methylase (20 U/μL) | 4 μL |
| Final volume | 100 μL |
| Component | Amount |
| Milli-Q water | 44 μL |
| 10× NEBuffer 2 | 10 μL |
| SAM (32 mM) | 2 μL |
| Unmethylated lambda DNA (450 μg/ mL) | 40 μL |
| SssI methylase (20 U/μL) | 4 μL |
| Final volume | 100 μL |