Table 2.

Top Popular Proteins for Common Disease Phenotypes^a

rank	fibrosis	cell death	inflammation	metabolic syndrome	oxidative stress	protein misfolding
1	TGFB1	CASP3	IL6	ADIPOQ	NFE2L2	PRNP
2	CTGF	BCL2	TNF	INS	CAT	HTT
3	ACTA1	BAX	CRP	SHBG	SOD1	SNCA
4	SMAD3	CASP9	IL1B	HSD11B1	HMOX1	TTR
5	SMAD2	CASP8	CXCL8	CRP	SOD2	IAPP
6	PNPLA3	ANXA5	CCL2	SLC12A3	GSR	TARDBP
7	KIF21A	BCL2L1	IL10	RARRES2	KEAP1	CANX
8	SLC17A5	CYCS	IL17A	LEP	GPX1	SOD1
9	GPT	PARP1	TLR4	ETV3	TXN	ATXN3
10	FN1	FASLG	IL1A	FABP4	NOX4	P4HB
11	TIMP1	TP53	ICAM1	APOB	GCLC	DNAJB2
12	SAMSN1	TNFSF10	VCAM1	NAMPT	OGG1	HSF1
13	SMAD7	MCL1	NLRP3	CLCNKB	PON1	ATXN1
14	IFNL3	BECN1	IL18	RETN	NQO1	DNAJB1
15	COL1A1	FAS	IL1RN	PPARA	GSTK1	RNF5
16	HPS1	XIAP	HMGB1	PPARG	PARK7	HSPA4
17	TM6SF2	AKT1	IL33	GPT	CYBB	CFTR
18	LGALS3	TNFRSF10B	SELE	RBP4	SOD3	HSPA5
19	HPS4	PDCD1	RNASE3	SAMSN1	PRDX5	ZFAND2A
20	POSTN	CASP7	CCL5	APOA5	CASP3	HSPA8

^aSymbols for top-20 proteins represented by their gene name for each common disease process are shown and ranked by WCD and their P values.