Figure 1.

The clinical and histological changes of arthritis in gp130F759. (A) Incidence and severity of clinical arthritis of gp130F759 (n=13; seven of male and six of female) is shown. The severity score for each mouse, the sum of scores for four limbs, was determined as described in Methods section and online supplementary figure 1. Onset of clinical arthritis was certified by the score higher than two. Severity scores are expressed as the mean±SD. (B) Representative arthritic joint sections from the mice with distinct severity scores. Slices of the joints were stained with H&E. (C) Results of Sirius red staining of the slice specimens obtained from the same mice used in (B) are indicated. WT, wild type.