Table 1.
Study participant characteristics and Copy Number Variant (CNV) distributions
| 610k Array N=2818 |
2.5M Array N=792 |
|||||
|---|---|---|---|---|---|---|
| Case | Control | Pvaluea | Case | Control | Pvaluea | |
| N | 1368 | 1450 | 449 | 343 | ||
| Age | ||||||
| Mean (range) | 60.1 (26-91) | 57.7 (20-90) | <0.001 | 62.2 (20-88) | 58.2 (22-93) | <0.001 |
| Study Site | ||||||
| Minnesota region (Mayo) | 325 | 467 | 449 | 343 | ||
| North Carolina (Duke) | 406 | 553 | 0 | 0 | ||
| Tampa Bay (Moffitt) | 152 | 139 | 0 | 0 | ||
| Toronto (U of Toronto) | 485 | 291 | 0 | 0 | ||
| Histotype (%) | ||||||
| Serous | 825 (60%) | 346 (77%) | ||||
| High grade | 410 (30%) | 303 (67%) | ||||
| Low grade/LMP | 121 (9%) | 43 (10%) | ||||
| Unknown | 294 (21%) | 0 | ||||
| Endometrioid | 241 (18%) | 30 (7%) | ||||
| Mucinous | 63 (5%) | 28 (6%) | ||||
| Clear cell | 112 (8%) | 15 (3%) | ||||
| Mixed cell | 38 (3%) | 25 (6%) | ||||
| Other | 89 (7%) | 5 (1%) | ||||
| CNV segments (No.) | ||||||
| All | 30877 | 33626 | 28578 | 21929 | ||
| Deletions | 23532 (76%) | 25028 (74%) | 11947 (42%) | 8821 (40%) | ||
| Duplications | 7345 (24%) | 8598 (26%) | 16631 (58%) | 13108 (60%) | ||
| CNV segments (Mean) | ||||||
| All | 22.6 | 23.2 | 0.93 | 63.7 | 63.9 | 0.63 |
| Deletions | 17.2 | 17.3 | 0.56 | 26.6 | 25.7 | 0.06 |
| Duplications | 5.4 | 5.9 | 1.00 | 37.0 | 38.2 | 0.92 |
| Average CNV length (Kb) | ||||||
| All | 77 | 80 | 0.99 | 48 | 49 | 0.93 |
| Deletions | 55 | 54 | 0.34 | 25 | 26 | 0.73 |
| Duplications | 144 | 146 | 0.64 | 65 | 66 | 0.77 |
a
Mean age was compared between cases and controls with the student t-test. Empirical p-values are reported for difference in CNV average number of segments and difference in average CNV length based on 10000 permutations.