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. 2019 Jul 2;9:9526. doi: 10.1038/s41598-019-45457-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of 1-D Epigenome annotations with respect to core and periphery nodes. (A) Core and periphery nodes in significantly core-periphery TADs in ES cells, NPCs, and CNs were intersected with genome-wide cell type-specific CTCF occupied sites, putative enhancers, and genes. (B) Zoom-in of the percent of core and periphery nodes intersecting annotations in TADs with significant core-periphery network structure.