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. 2019 Jul 2;9:9526. doi: 10.1038/s41598-019-45457-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Constitutive and cell-specific CTCF occupied sites are strongly enriched at core vs. periphery nodes across cell types. (A–C) Observed/Expected heatmap examples in (A) ES cell (B) NPC and (C) CN TADs with significant core-periphery architecture illustrating co-localization of constitutive CTCF occupancy with core nodes and not with periphery nodes. (D–K) Bar plots comparing proportions of core and periphery nodes that intersect the annotation of interest vs. do not intersect the annotation of interest. Odds ratios (OR) are reported for all plots. (D) Constitutive CTCF, (E) ES-only enhancers, (F) NPC-only enhancers, (G) CN-only enhancers, (H) ES-only genes, (I) NPC-only genes, (J) CN-only genes, (K) Inactive genes. (L) Summary of Odds ratios for 1-D Epigenome annotation enrichment in core vs. periphery nodes for all TADs with significant core-periphery structure in cortical neurons.