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. 2019 Jul 2;9:9563. doi: 10.1038/s41598-019-46032-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological photomicrograph of (A) the normal sheep nasal mucosa (control) (magnification size × 20); (B) nasal mucosa after treatment with hydrogels without additives. Hypotrophy in the Bowman’s gland and cellular infiltration in the connective tissue lamina propria surrounding the gland are perceivable; (C) nasal mucosa after treatment with the PVP + PEG hydrogels; (D) histological characterization of nasal mucosa after using chitosan hydrogel; and (E) nasal mucosa after treatment with thiolated chitosan hydrogel (magnification size × 10).