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. 2019 Jul 2;9:9549. doi: 10.1038/s41598-019-46014-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Targeted elimination of CD133+ or OCT4/SOX2+ GSCs abolishes U87 tumor growth in vivo. (A,E) and (B,F) Pseudo-color BLI images of representative mice showing intensity of PLuc and RLuc activity, respectively, in response to GCV treatment. BLI images are superimposed on black & white images of the corresponding animal; (C,G) Graphs showing changes in tumor PLuc activity in response to GCV targeting of CD133 (C) or OCT4/SOX2 (G) positive cells; PHCs, Photon counts; Data points represent interquartile range of the median, *P < 0.5, **P < 0.01; n = 10/group. (D,H) Kaplan-Meier survival graphs of mice injected with U87-G-P/CD133-R-R-tTK (D) or U87-G-P/OCT4/SOX2-R-R-tTK (H) (P < 0.0001 in both cases).