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. 2019 Jul 2;9:9550. doi: 10.1038/s41598-019-44844-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Observed ΔSpO₂ plotted against that predicted ΔSpO₂ from the least squares regression after logarithmic transformation for ΔEE, Δ ${\dot{V}}_{E}$ , and ΔHR: ΔSpO₂ = −3.78ΔEE − 0.48ΔV_E − 13.45ΔHR for men and ΔSpO₂ = −9.18ΔEE + 1.64ΔV_E − 14.21ΔHR for women; see text (upper panel). Line indicates y = x. Each symbol are the same as in Fig. 2. Contributions of EE (gray segments), ${\dot{V}}_{E}$ (black segments) and HR (white segments) to predict changes in SpO₂ are shown (lower panel).