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. 2019 Jun 26;11:156. doi: 10.3389/fnagi.2019.00156

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Copyright © 2019 Wan, Ji, Schrepfer, Gong, Wang and Corfas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signs of age-related hearing loss in FVB/N mice are detectable at 5 months of age. (A) Distortion-product otoacoustic emission (DPOAE) threshold, (B) auditory brainstem response (ABR) threshold, (C) ABR peak 1 amplitude, and (D) latency were measured on 2 (n = 10), 5 (n = 12), 9 (n = 12), 18 (n = 12) and 24 (n = 10) month old FVB/N mice. ABR peak 1 latency was analyzed at 80 dB sound pressure level (SPL) and amplitude analyzed by averaging 70 and 80 dB SPL. **p < 0.01 and ****p < 0.0001 by two-way ANOVA comparing to 2-month-old mice. (E) ABR peak 1 amplitude was plotted against the acoustic stimulus level (10–80 dB SPL) at 5.6, 8, 11.3, 16, 22.6 and 32 kHz. Input-output curves of ABR P1 amplitudes from 5, 9, 18 and 24-month-old mice were significantly different from that of 2-month-old mice at all frequencies tested (p < 0.0001 by two-way ANOVA).