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. 2019 Jun 26;11:156. doi: 10.3389/fnagi.2019.00156

Figure 2.

Figure 2

Age-related defects in vestibular evoked potentials (VsEPs) are seen only in 24 month-old-mice. (A) VsEP threshold, (B) VsEP peak 1 latency and (C) VsEP peak 1 amplitude at 2.5 dB re 1 g/ms were measured on 2 (n = 10), 5 (n = 10), 9 (n = 6), 18 (n = 15) and 24 (n = 11) month old FVB/N mice. Data from males and females are presented as triangles and circles respectively. ***p < 0.001 and ****p < 0.0001 by one-way ANOVA comparing to 2-month-old mice followed by Dunn’s post-test. (D) VsEP threshold, (E) VsEP peak 1 latency and (F) VsEP peak 1 amplitude at 2.5 dB re 1 g/ms of either male or female mice were analyzed separately. The numbers of males and females at each point are 9 and 1 (2 months), 4 and 6 (5 months), 7 and 8 (18 months), 2 and 4 (9 months), 8 and 3 (24 months) respectively. *p = 0.03 by two-way ANOVA. (G) Comparison of the time course of age-related changes in VsEP peak 1 amplitude and ABR peak 1 amplitude. VsEP and ABR (8, 16, 32 kHz) peak 1 amplitude was normalized to data from 2-month-old mice. The relative amplitude was plotted against age of the mice. ***p < 0.001 and ****p < 0.0001 by two-way ANOVA comparing to changes in VsEP amplitude.