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. 2019 Jun 26;11:156. doi: 10.3389/fnagi.2019.00156

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Copyright © 2019 Wan, Ji, Schrepfer, Gong, Wang and Corfas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of calyceal innervations and ribbons of type I hair cells in 24-month-old utricular extrastriola. (A) Co-labeling of calyceal terminals (Tuj1), hair cells (Myo7a) and synaptic ribbons (Ctbp2) in 2 and 24 months old utricular extrastriolar region. (B) Co-labeling of calyceal terminals (Tuj1), hair cells (Myo7a) and type II hair cells + supporting cells (Sox2) in 2 and 24 months old utricular extrastriolar region. Asterisks (*) indicate Sox2 type I hair cells that had lost calyceal innervations in 24-months-old utricle.