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. 2019 Jun 26;9:545. doi: 10.3389/fonc.2019.00545

Figure 1.

Figure 1

Inhibitory effects of rotundic acid (RA) on HCC and endothelial cell growth. MTT assays were performed to determine the effects of RA on HCC and endothelial cell growth. RA inhibited the cell viability and proliferation of (A) HepG2 cells, (B) SMMC-7721 cells in a time and dose-dependent manner. The dose survival curves of (C) HepG2 cells, (D) SMMC-7721 cells, (E) HUVEC's, and (F) LO2 cells after RA treatment. RA exhibited no significant toxicity on the normal hepatic LO2 cells. Data are represented as mean ± SD (n = 3; $$, ##, **p ≤ 0.01 and #, *p ≤ 0.05 vs. control).