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Inhibitory effects of RA on the migration and invasion of SMMC-7721 cells. SMMC-7721 cells were treated with various concentrations of RA and subjected to migration and invasion assays. RA treatment prevented the (A,B) wound closure and (C,D) extracellular matrix invasion of SMMC-7721 cells in a concentration-dependent manner (n = 3 or more; **p ≤ 0.01, *p ≤ 0.05 vs. control).
