Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 26;9:545. doi: 10.3389/fonc.2019.00545

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Roy, Guan, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

RA abrogates in vivo tumor formation in Balb/c nude mice. (A) Schematic representation of the experimental protocol. (B) Tumor-bearing control and RA-treated mice. (C) Mice were euthanized after 60 days; tumors were extracted, weighed, and photographed. Significant reduction of (D) tumor volumes and (E) tumor weights were observed in the RA-treated group vs. the control group. (F) RA did not yield any adverse effects on the mice body weights (**p ≤ 0.01, *p ≤ 0.05). Western blot of tumor tissue lysates indicated that RA. (G) attenuated the expressions of Ki-67, CD-31, and induced apoptosis in tumor cells. (H) RA modulated the AKT/mTOR and MAPK pathways in vivo (n = 3).