Table 2.

Correlations with PD status for potential microbiome confounders.

Variable	Pearson correlation coefficient with PD	Use for PD status comparisons	Use for progression comparisons
Rome III 9–15 sum score	0.432	Yes	No
RLS	0.419	Yes	No
Wexner total	0.418	Yes	No
Rome III IBS criteria fulfilled	0.280	Yes	No
Medication anticholinergic	0.161	Yes	No
Diet PC1	0.145	Yes	No
BMI	0.094	Yes	No
Age at stool collection	0.061	Yes	No
Sex	0.016	Yes	No
MMSE total	−0.159	Yes	No
Medication ACE-I/ARB	−0.160	Yes	No
Medication Ca channel blockers	−0.165	Yes	No
Medication warfarin	−0.205	Yes	No
Medication statin	−0.332	Yes	No
History TIA / ischemic stroke	−0.364	Yes	No
Medication dopamine agonist	0.807	No	Yes
LED	0.753	No	Yes
Medication MAO inhibitor	0.736	No	Yes
NMSQuest total	0.714	No	Yes
Medication dopa	0.662	No	Yes
NMSS total	0.607	No	Yes
RBDSQ	0.580	No	Yes
SDQ total	0.529	No	Yes
SCS PD total	0.520	No	Yes
GDS 15	0.491	No	Yes
Medication COMT inhibitora	0.307	No	Yes
Sniffin’ Sticks	−0.769	No	Yes

Table legend: RLS: Restless Legs Syndrome, IBS: Irritable Bowel Syndrome, PC: Principal Component, BMI: Body Mass Index, MMSE: Mini-Mental State Examination, ACE-I/ARB: angiotensin-converting-enzyme inhibitor / angiotensin II receptor blocker, TIA: Transient Ischemic Attack, LED: Levodopa Equivalent Dose, MAO: Monoamine Oxidase, NMSQuest: Non-Motor Symptoms Questionnaire, NMSS: Non-Motor Symptoms Scale, RBDSQ: REM Sleep Behavior Disorder Screening Questionnaire, SDQ: Swallowing Disturbance Questionnaire, SCS-PD: Sialorrhea Clinical Scale for PD, GDS 15: 15-item Geriatric Depression Scale, COMT: catechol-O-methyl transferase.

^aCOMT inhibitor variable used only for progression although |Pearson's r| < 0.5, since only PD patients take this medication.