Table 7.
Beta diversity comparisons of stable and progressed PD patients and confounding variables.
|
A. Adonis: Timepoint + progression category (no confounders) | ||
|---|---|---|
| Level | p-value (Timepoint) | p-value (progression) |
| OTU | 1.000 | 0.245 |
| Genus | 0.945 | 0.344 |
| Family | 0.850 | 0.142 |
|
B. Adonis: Timepoint + progression category single confounder | |||
|---|---|---|---|
| Variable | p-value (OTUs) | p-value (genera) | p-value (families) |
| SDQ | 0.012 | 0.007 | 0.010 |
| COMT inhibitors | 0.001 | 0.001 | 0.001 |
| Levodopa entacapone (mg) | 0.001 | 0.001 | 0.001 |
| Entacapone (mg) | 0.001 | 0.001 | 0.001 |
| NMSQuest | 0.003 | 0.018 | 0.137 |
| SCS-PD | 0.001 | 0.005 | 0.166 |
| Statins | 0.010 | 0.038 | 0.065 |
| GDS 15 | 0.016 | 0.395 | 0.308 |
| L-dopa | 0.025 | 0.061 | 0.088 |
| NMSS | 0.018 | 0.070 | 0.306 |
| RBDSQ | 0.007 | 0.131 | 0.079 |
| Ropinirole (mg) | 0.365 | 0.045 | 0.223 |
| Dopamine agonists | 0.050 | 0.365 | 0.074 |
| MAO inhibitors | 0.545 | 0.826 | 0.442 |
| Sniffin’ Sticks | 0.422 | 0.342 | 0.093 |
| Acetylsalicylic acid | 0.430 | 0.824 | 0.943 |
| PIGD score Jankovic | 0.057 | 0.176 | 0.484 |
| Pramipexole (mg) | 0.075 | 0.060 | 0.059 |
| C. Timepoint + progression category + multiple confounders | ||||||
|---|---|---|---|---|---|---|
| adonis2 |
envfit |
|||||
| Variable | p-value (OTUs) | p-value (genera) | p-value (families) | p-value (OTUs) | p-value (genera) | p-value (families) |
| Timepoint | 0.865 | 0.515 | 0.582 | 0.797 | 0.372 | 0.074 |
| Progression | 0.396 | 0.334 | 0.204 | 0.330 | 0.592 | 0.889 |
| COMT inhibitors | 0.001 | 0.001 | 0.001 | <0.001 | 0.295 | 0.888 |
| NMSQuest | 0.036 | 0.027 | 0.321 | 0.227 | 0.024 | 0.102 |
| SCS-PD | 0.002 | 0.035 | 0.271 | 0.031 | 0.427 | 0.479 |
| Statins | 0.042 | 0.214 | 0.442 | 0.475 | <0.001 | 0.005 |
| SDQ | 0.114 | 0.116 | 0.067 | NA | NA | NA |
| GDS 15 | 0.127 | 0.804 | 0.660 | NA | NA | NA |
| L-dopa | 0.421 | 0.344 | 0.208 | NA | NA | NA |
| NMSS | 0.447 | 0.216 | 0.498 | NA | NA | NA |
| RBDSQ | 0.062 | 0.513 | 0.312 | NA | NA | NA |
| Ropinirole (mg) | 0.411 | 0.098 | 0.440 | NA | NA | NA |
Table legend: Statistically significant p-values are marked in bold italic font. OTU: Operational Taxonomic Unit, SDQ: Swallowing Disturbance Questionnaire, COMT: catechol-O-methyl transferase, NMSQuest: Non-Motor Symptoms Questionnaire, SCS-PD: Sialorrhea Clinical Scale for PD, GDS 15: 15-item Geriatric Depression Scale, NMSS: Non-Motor Symptoms Scale, RBDSQ: REM Sleep Behavior Disorder Screening Questionnaire, MAO: Monoamine Oxidase, PIGD: postural instability and gait difficulty.