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. 2019 Jun 26;7:103. doi: 10.3389/fcell.2019.00103

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Copyright © 2019 Gill, Ly, Kim, Saunders, Fong, Young, Luxton and Rowat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fibroblasts lacking LINC complexes (SUN1/2, SUN2), A-type lamins (LMNA), or lamin B1 (LMNB1) have increased deformability relative to controls. PMF measurements of the indicated MEF lines. (A) PMF conditions: 10 μm pore membrane, 2.1 kPa for 50 s. (C) PMF conditions: 10 μm pore membrane, 2.1 kPa for 40 s. Each data point represents the mean ± SD. Statistical significance was determined using Student’s t-test. (B,D) Cell size data. Boxplots show 25 and 75th percentiles; line shows median; whiskers denote 10 and 90th percentiles. Statistical significance was determined using Mann–Whitney U-test. All data were obtained from three independent experiments. ^∗∗∗p < 0.001; ^∗∗p < 0.01; not significant (NS) p > 0.05.