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. 2019 Jun 26;13:674. doi: 10.3389/fnins.2019.00674

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Copyright © 2019 Ni, Rui, Lin, Li, Liu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of 2-BFI on microglia activation, neutrophil infiltration, and IL-1β secretion after TBI. (A) Representative immunofluorescence staining images of Iba1 (green) and MPO (green) in the pericontusional cortex at 72 h after TBI. Bar = 25 μm. (B) Quantification of microglial activation based on the scores for both microglial number and morphology. (C) Quantitative analysis shows that 2-BFI inhibited the increase in the number of MPO-positive cells after TBI. (D) 2-BFI inhibited the elevation in IL-1β mRNA levels in the pericontusional cortex at 72 h after TBI. (E) TBI-induced IL-1β secretion was also reduced by 2-BFI treatment. n = 6 animals per group. Data are expressed as the mean ± SEM; ^∗P < 0.05 vs. sham; ^#P < 0.05 vs. TBI + vehicle.