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. 2019 Jun 26;9:225. doi: 10.3389/fcimb.2019.00225

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Copyright © 2019 Zhou, Li, Xu, Wang, Bai, Feng, Su, Chen, Wang, Liu, Wang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CEH combined with CDDP chemotherapy inhibits the growth of ESCC in vivo. (A) The timeline for ESCC xenografts mouse model construction and chemotherapy strategy. (B) Time courses of animal body weight. (C) Time courses of xenograft tumor volume. (D) Xenograft tumor weight histogram. (E) Tumor inhibition rate of CEH, CDDP, and combination chemotherapy strategies. (F) TUNEL staining of paraffin sections of xenograft tumor tissues. Error bars represent mean ± SD. N, negative control; M, model control; CDDP, CDDP chemotherapy; CEH, cepharanthine hydrochloride chemotherapy; Comb, combined chemotherapy strategy; ns, no significant difference. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.