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. 2019 Jun 26;9:225. doi: 10.3389/fcimb.2019.00225

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Copyright © 2019 Zhou, Li, Xu, Wang, Bai, Feng, Su, Chen, Wang, Liu, Wang, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Combination of CEH with CDDP can improve the intestinal microbes structural changes caused by chemotherapy. (A–C) T-test of species differences at the phylum level. (A) Comparison between M and CDDP. (B) Comparison between CDDP and CEH. (C) Comparison between CDDP and Comb. (D–F) T-test of species differences at the genus level. (D) Comparison between M and CDDP. (E) Comparison between CDDP and CEH. Mean relative abundance of species which with significant difference within the group (A–E left panel). Difference confidence display, the difference value of the mean of relative abundance (A–E right panel). (F) Comparison between CDDP and Comb. (G) LEfSe (LDA Effect Size) analysis of species with significant differences between M and CDDP. (H) LEfSe analysis of species with significant differences between CDDP and Comb. N, negative control; M, model control; CDDP, CDDP chemotherapy; CEH, cepharanthine hydrochloride chemotherapy; Comb, combined chemotherapy strategy.