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. 2019 Jun 26;10:716. doi: 10.3389/fphar.2019.00716

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Copyright © 2019 Zhang, Jin, Chen, Chen, He, Yang, Ma, Xiao, Xi, Luo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The puncture needle is connected to the bio-signal acquisition and analysis system and placed horizontally at the same level as the tumor. The needle was inserted horizontally into the center of the tumor under ultrasound guidance, and the stable reading as the corresponding interstitial fluid pressure (IFP) value. (B) The therapeutic probe of ultrasonic cavitation therapeutic instrument is fixed on the iron frame, and the therapeutic probe is placed on the corresponding body surface of the tumor with sufficient coupling, and the tumor is irradiated with energy of 1 MPa, 3 MPa, and 5 MPa according to the set treatment parameters in each group, respectively.