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. 2019 Jun 26;10:716. doi: 10.3389/fphar.2019.00716

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Copyright © 2019 Zhang, Jin, Chen, Chen, He, Yang, Ma, Xiao, Xi, Luo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The tumor cells are disordered, different in size, densely arranged, large nuclei stain and nuclei dimorphism. The tumor blood vessels were branched and their structure was clear. Furthermore, the vessel wall was intact and continuous, with no obvious damage. There are no red blood cells observed at the periphery of the vessels in US group, MB group, and BC group. There are some red blood cells observed at the periphery of the vessels in 1MPa-USMB group. The microvascular congestion and expansion can be seen in the injured area, the vessel-wall is incomplete (solid arrow), and red blood cells can be seen around the vessels (asterisk) in 3MPa-USMB group and 5MPa-USMB group.