FIG 3.

The periplasmic multidrug binding sites of AdeB. (A) The periplasmic cleft entrance. Residues that are predicted to be important for selectivity are shown as gray sticks. (B) The F-loop that forms part of the proximal multidrug binding site. Residues that are supposed to be important for drug binding in this F-loop are shown as cyan sticks. The G-loop that is thought to be important for delivering a drug molecule to the distal multidrug binding site is colored green. The G-loop residues are shown as green sticks. (C) The hydrophobic patch of the distal binding site. Residues that are responsible for forming this hydrophobic patch are shown as orange sticks. The secondary structural elements of AdeB are colored yellow.