Fig. 1.

Rg1 enhances muscle size and function. (A) Body weights of 3-month-old control-fed and Rg1-fed mice for 4 weeks. (B) Daily water intake from control- and Rg1-fed mice. (C) Fasting blood glucose levels over 16 h. (D) Heart weights from control- and Rg1-treated mice. (E) Liver, white adipose tissue (WAT), and brown adipose tissue (BAT) mass of control- and Rg1-treated mice. (F) Weights of four muscle types from control- and Rg1-fed mice. The data represent the mean ± SD. *p < 0.05. ns, not significant. (n = 4–5). (G) Representative images of hematoxylin eosin–stained tibialis anterior (TA) muscle from control- and Rg1-treated mice. Scale bar = 50 μm. (H) Quantification of cross-sectional area (CSA) from the muscles of control- or Rg1-fed mice (n = 4). The data represent the mean ± SEM. *p < 0.05, **p < 0.01. (I) Measurement of grip strength in control- or Rg1-treated mice for 3 weeks (n = 10). The data represent the mean ± SD. **p < 0.01. ns, not significant.

EDL, extensor digitorum longus; GAS, gastrocnemius; SD, standard deviation; SEM, standard error of mean; SOL, soleus.