Table 1.
Characteristics of the main nucleoid-associated proteins in bacteria.
| NAPs | Size (kDa) | Accession ID | Representative organism | Presence in MGEs | Acknowledged function |
|---|---|---|---|---|---|
| H-NS family proteins | |||||
| H-NS | 15 | P0ACF8 | Escherichia coli | Y | Xenogeneic silencing. Nucleoid structuring |
| StpA | 15 | P0ACG1 | Escherichia coli | ND | Functional analog of H-NS |
| MvaT | 14 | Q9HW86 | Pseudomonas aeruginosa | Y | Functional analog of H-NS |
| Ler | 14 | A0A0H0PFT0 | Escherichia coli | Y | Homologue and antagonist of H-NS. Activator of LEE |
| Hfp | Escherichia coli | Y | Functional analog of H-NS | ||
| BpH3 | 14 | O07507 | Bordetella pertussis | ND | Functional analog of H-NS. Essential for B. pertussis |
| Bv3F | 13 | A4JS72 | Burkholderia vietnamiensis | ND | |
| HvrA | 11 | P42505 | Rhodobacter capsulatus | ND | |
| Lsr2 | 12 | P9WIP7 | Mycobacterium tuberculosis | ND | Functional analog of H-NS |
| XrvA | 15 | Q56835 | Xanthomonas oryzae | ND | |
| Rok | 22 | O34857 | Bacillus subtilis | ND | Functional analog of H-NS. Repressor of ComK |
| HU/IHF family proteins | |||||
| HU | 9 | P0ACF0 | Escherichia coli | Y | DNA replication, repair, recombination packaging |
| IHF | 11 | P0A6X7/P0A6Y1 | Escherichia coli | Y | DNA transposition, recombination, plasmid replication |
| Fis family proteins | |||||
| Fis | 11 | P0A6R3 | Escherichia coli | ND | Gene regulation, nucleoid architecture, DNA remodeling |
| Other | |||||
| Lrp | 19 | P0ACJ0 | Escherichia coli | Y | Gene regulation |
| EbfC | 11 | O51418 | Borrelia burgdorferi | ND | Gene regulation |
| NdpA | 37 | A0A024L1K9 | Escherichia coli | Y | |