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. 2019 Apr 1;28(14):2330–2338. doi: 10.1093/hmg/ddz065

Figure 4.

Figure 4

Overexpression of MBNL1 worsens the myopathy in DM200 mice. (A) H&E staining analysis of skeletal muscle (quadriceps femoris) shows increased central nuclei and smaller fiber size in DM200+: MBNL1-OE14685+/WT mice as compared to the DM200+ mice alone. (B) Quantification of centrally nucleated fibers in DM200+ D−, DM200+ D+, DM200+: MBNL1-OE14685+/WT D− and DM200+: MBNL1-OE14685+/WT D+ mice. (C) Percentage of small fibers (average fiber cross-sectional area < 30 μm) in skeletal muscle from DM200+ D−, DM200+ D+, DM200+: MBNL1-OE14685+/WT D− and DM200+: MBNL1-OE14685+/WT D+ mice. At least n = 4 mice analyzed each group; ***P < 0.001. Errors bars are mean ± SEM. (Student’s t-test).