Table 3.
Ventilatory and metabolic responsiveness during hypoxia in behaving rats during quiet rest.
| VEH (n = 10) | ABX (n = 10) | VEH-FMT (n = 10) | ABX-FMT (n = 10) | One-way ANOVA | |
|---|---|---|---|---|---|
| Δ fR(brpm) | 68 ± 20 | 63 ± 20 | 57 ± 21 | 65 ± 17 | 0.585 |
| Δ VE (ml/min/100 g) | 43 ± 8 | 36 ± 14 | 36 ± 9 | 43 ± 13 | 0.244 |
| Δ VT (ml/100 g) | 0.07 ± 0.08 | 0.06 ± 0.08 | 0.08 ± 0.06 | 0.02 ± 0.08 | 0.35 |
| Δ VT/Ti (ml/s/100 g) | 4.4 ± 0.7 | 4.1 ± 1.1 | 3.6 ± 0.7 | 4.1 ± 0.6 | 0.168 |
| Δ Ti (ms) | −87 ± 28 | −95 ± 41 | −87 ± 32 | −92 ± 34 | 0.933 |
| Δ Te (ms) | −236 ± 62 | −239 ± 78 | −208 ± 72 | −263 ± 106 | 0.153 |
| Δ VO2 (ml/min/100 g) | −1.0 ± 0.7 | −1.4 ± 1.1 | −0.9 ± 0.8 | −0.86 ± 0.9 | 0.522 |
| Δ VCO2 (ml/min/ 100 g) |
0.2 ± 0.5 | −0.005 ± 0.3 | 0.09 ± 0.2 | 0.02 ± 0.2 | 0.444 |
| Δ VE/VCO2 | 22 ± 10 | 20 ± 9 | 18 ± 6 | 24 ± 5 | 0.335 |
fR, respiratory frequency (brpm, breaths per min); VE, minute ventilation; VT, tidal volume; VT/Ti, mean inspiratory flow; Ti, inspiratory time; Te, expiratory time; SD1, short-term respiratory timing variability; SD2, long-term respiratory timing variability VO2, oxygen consumption; VCO2, carbon dioxide production; VE/VCO2, ventilatory equivalent; VEH, autoclaved deionised water; ABX, antibiotic-treated; VEH-FMT, VEH followed by faecal microbiota transfer; ABX-FMT, antibiotic-treated followed by faecal microbiota transfer. Data are shown as mean ± SD and were statistically compared using one-way ANOVA with Bonferroni post hoc where appropriate. Each p-value is adjusted to account for multiple comparisons. Data are expressed as absolute change from baseline (Δ parameter).