Table 4.
Respiratory timing variability, apnoeas and sighs during hypoxia in behaving rats during quiet rest.
| VEH (n = 10) | ABX (n = 10) | VEH-FMT (n = 10) | ABX-FMT (n = 10) | One-way ANOVA | |
|---|---|---|---|---|---|
| Ti SD1 (ms) | 28 ± 5 | 30 ± 6 | 30 ± 6 | 29 ± 7 | 0.744 |
| Ti SD2 (ms) | 57 ± 10 | 67 ± 19 | 59 ± 9 | 57 ± 16 | 0.272 |
| Te SD1 (ms) | 79 ± 28 | 89 ± 35 | 77 ± 15 | 80 ± 31 | 0.804 |
| Te SD2 (ms) | 140 ± 27 | 147 ± 32 | 132 ± 37 | 130 ± 42 | 0.699 |
| Ttot SD1 (ms) | 102 ± 31 | 112 ± 38 | 99 ± 15 | 102 ± 33 | 0.803 |
| Ttot SD2 (ms) | 217 ± 30 | 237 ± 35 | 217 ± 32 | 203 ± 64 | 0.405 |
| Apnoea index (events/h) | 0.6 ± 1.9 | 3.0 ± 4.2 | 1.2 ± 2.5 | 1.2 ± 2.5 | 0.398 |
| Sigh frequency (events/h) | 148 ± 35 | 166 ± 71 | 172 ± 46 | 160 ± 29 | 0.715 |
Ti, inspiratory time; Te, expiratory time; Ttot, total breath duration; SD1, short-term respiratory timing variability; SD2, long-term respiratory timing variability; VEH, autoclaved deionised water; ABX, antibiotic-treated; VEH-FMT, VEH followed by faecal microbiota transfer; ABX-FMT, antibiotic-treated followed by faecal microbiota transfer. Data are shown as mean ± SD and were statistically compared using one-way ANOVA or non-parametric Kruskal-Wallis test where appropriate.