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Purported functional effects of administered recombinant proteins ephrin-B1-Fc, EphB1-Fc, and EphB4.
| Recombinant protein | Target | Effects | |
|---|---|---|---|
| Forward signaling | Reverse signaling | ||
| ephrin-B1-Fc | EphB | ↑ | ↓ |
| EphB1-Fc | ephrin-B | ↓ | ↑ |
| EphB4 | ephrin-B | ↓ | ↓ |
↑, Increased; ↓, Decreased.
Adapted from Barquilla and Pasquale, 2015.
