Skip to main content
. 2019 Jun 26;10:696. doi: 10.3389/fphar.2019.00696

Figure 2.

Figure 2

HIF-1α gene structure, stability, and activation. (A) Normal oxygen level induces the degradation of HIF-1α by hydroxylation or acetylation-mediated VHL binding and also transcriptional activity of HIF-1α. (B) Under hypoxic conditions, VHL is not prolyl-hydroxylated and cannot bind to HIF-1α protein, which leads to a decreased rate of HIF-1α degradation. Hypoxia promotes the interaction of HIF-1α within CBP/p300 and induces dimerization of HIF-1α with HIF-1β, which results in HIF-1 transcription factor formation. The active HIF-1 will further bind to HREs and activate the transcription of downstream genes.