Table 2.
Chinese Herbal Medicines and Their Molecular Targets That Are Regulated by the HIF-1 Pathway in Cancer.
| Herb Medicine | Molecular Target | Reference |
|---|---|---|
| Inhibitors of HIF-1 mRNA and/or protein expression | ||
| Scutellaria barbata | HIF-1α protein expression | (Shiau et al., 2014) |
| Antrodia cinnamomea | HIF-1α protein expression | (Liu et al., 2013) |
| L. obtusiloba extract | HIF-1α protein expression | (Freise et al., 2011) |
| Pien Tze Huang | HIF-1α mRNA and protein expression | (Chen et al., 2015) |
| Yi Ai Fang | HIF-1α protein expression | (Hou et al., 2016) |
| Changweiqing | HIF-1α protein expression | (Li et al., 2011) |
| Erxian decoction | HIF-1α protein expression | (Yu et al., 2012) |
| Zengmian Yiliu granule | HIF-1α mRNA and protein expression | (Hu et al., 2012) |
| Buyang Huanwu decoction | HIF-1α protein expression | (Min et al., 2016) |
| Fraxinellone | HIF-1α protein expression | (Xing et al., 2018) |
| Oridonin | HIF-1α protein expression | (Li C. et al., 2018) |
| Catalpol | HIF-1α protein expression | (Zhu et al., 2017) |
| Pseudolaric acid B | HIF-1α protein expression | (Wang et al., 2017) |
| Andrographolide | HIF-1α protein expression | (Shi et al., 2017) |
| Baicalein | HIF-1α protein expression | (Wang and Jiang, 2015) |
| Berberine | HIF-1α protein expression | (Fu et al., 2013; Yang et al., 2013; Zhang et al., 2014a; Zhang C. et al., 2014; Tsang et al., 2015) |
| Isoliquiritigenin | HIF-1α protein expression | (Wang et al., 2013) |
| alpha-MMC | HIF-1α protein expression | (Pan et al., 2014) |
| Total triterpenoid saponins | HIF-1α protein expression | (Jia et al., 2017) |
| Licorice | HIF-1α protein expression | (Park et al., 2016) |
| Tanshinone IIA | HIF-1α protein expression | (Fu et al., 2014; Sui et al., 2017) |
| Triptolide | HIF-1α protein expression | (Li et al., 2018b) |
| Ginsenoside Rg3 | HIF-1α mRNA and protein expression | (Wang et al., 2009; Chen et al., 2010) |
| 20(R)-ginsenoside Rg3 | HIF-1α mRNA and protein expression | (Geng et al., 2016) |
| Schizandrin B | HIF-1α mRNA and protein expression | (Lv et al., 2015) |
| Rhaponticin | HIF-1α mRNA and protein expression | (Kim and Ma, 2018) |
| Cinnamon (CE) | HIF-1α mRNA and protein expression | (Zhang et al., 2017) |
| Celastrol | HIF-1α mRNA and protein expression | (Huang et al., 2011) |
| Curcumin | HIF-1α mRNA and protein expression | (Bae et al., 2006; Das and Vinayak, 2014; Li et al., 2018a) |
| Inhibitors of HIF-1 transcriptional activity | ||
| Triptolide | HIF-1α transcriptional activity | (Zhou et al., 2010) |
| Scutellaria barbata | HIF-1α transcriptional activity | (Shiau et al., 2014) |
| Inhibitors of signal transduction pathways | ||
| Methanolic extract | mPGES-1–PGE2–HIF-1α | (Ranjbarnejad et al., 2017a) |
| Jianpi-Jiedu formula | mTOR–HIF-1α–VEGF | (Mao et al., 2016) |
| Vanillin | STAT3–HIF-1α | (Park et al., 2017) |
| Garcinol | mPGES-1–PGE2–HIF-1α | (Ranjbarnejad et al., 2017b) |
| Diphyllin | mTORC1–HIF-1α–VEGF | (Chen H. et al., 2018) |
| Imperatorin | mTOR–p70S6K–4E-BP1, MAPK | (Mi et al., 2017) |
| Shikonin | mTOR-p70S6K–4E-BP1 | (Li M. et al., 2017) |
| Tanshinone IIA | mTOR-p70S6K-4E-BP1 | (Wang X. et al., 2017) |
| Celastrol | mTOR-p70S6K–eIF4E, ERK1/2 | (Ma et al., 2014) |
| 5,3’-Dihydroxy-6,7,4’-trimethoxyflavanone (DHTMF) | PI3K-Akt-mTOR | (Kim et al., 2015) |
| Ruscogenin | PI3K-Akt-mTOR | (Hua et al., 2018) |
| Cryptotanshinone | PI3K-Akt-mTOR | (Zhang et al., 2018) |
| PME and PZP | PI3K-Akt | (Sathya et al., 2010) |
| Delphinidin | PI3K-Akt-mTOR-p70S6K, ERK | (Kim et al., 2017) |
| Gallic acid | PTEN–AKT–HIF-1α | (He et al., 2016) |
| Emodin | TRAF6–HIF-1α–VEGF | (Shi and Zhou, 2018) |
| Celastrol | ROS-Akt-p70S6K | (Han et al., 2014) |
| Triptolide | ERK1/2–HIF-1α | (Liu H. et al., 2018) |
| Curcumin | DEC1–HIF-1α | (Wang X. et al., 2017) |