Fig. 3.

Diagnostic capacity for gastric cancer of the identified 19 serum protein signature by elastic-net logistic regression. (A) Diagnostic performances of different protein combinations. Proteins are sorted according to the absolute coefficient from the largest to the smallest. “ROC test P" is the p-value of the comparison of ROC curves generated from successive protein combinations with one more protein added at a time. Coef., coefficient. ROC, receiver operator characteristics. *, p < 0·05. (B) Overlaid ROC curves of each of the combinations from two to 19 serum proteins. Comb, combination. (C) Protein-protein interactions among the 19 proteins assessed with the STRING database.