Table 1.
Summary of GnRH neuron responses to optogenetic activation. Animal number (N) is given in headings. Numbers of cells responding are given in the table. * p < .001 Chi-square32,3 test comparing the proportion of cells showing immediate activation in diestrous females and PNA females.
| 2 Hz |
10 Hz |
20 Hz |
||
|---|---|---|---|---|
| (N = 7−8) | (N = 7−8) | (N = 9−12) | ||
| Male | No response | 6/9 (67%) | 5/9 (56%) | 14/21 (67%) |
| Delayed activation | 1/9 (11%) | 1/9 (11%) | 1/21 (5%) | |
| Immediate activation | 1/9 (11%) | 2/9 (22%) | 4/21 (19%) | |
| Immediate inhibition | 1/9 (11%) | 1/9 (11%) | 2/21 (10%) | |
| Female | No response: | 7/10 (70%) | 9/15 (61%) | 18/29 (62%) |
| Delayed activation: | 1/10 (10%) | 2/15 (13%) | 5/29 (17%) | |
| Immediate activation: | 1/10 (10%) | 2/15 (13%) | 4/29 (13%) | |
| Immediate inhibition: | 1/10 (10%) | 2/15 (13%) | 2/29 (7%) | |
| PNA female | No response: | 25/27 (93%) | ||
| Delayed activation: | 0/27 (0%) | |||
| Immediate activation: | 2/27 (7%)* | |||
| Immediate inhibition: | 0/27 (0%) |