Effect of Different Concentrations of NAGLU-IGF2 and Unmodified NAGLU on Total Heparan Sulfate Storage after Extended Exposure of MPS IIIB Fibroblasts
HS measurements were taken from confluent cultures of MPS IIIB-patient-derived fibroblasts that were either not treated (untx, black bar) or treated with increasing amounts of either NAGLU-IGF2 (blue bars) or unmodified NAGLU (gray bars) for 9 days in culture. Treatments were administered in triplicate, with the results shown as the mean ± SD.