miR-381 suppressed the proliferation, migration and invasion of PCa cells. (A) MTT assay was performed to examine LNCaP cell proliferation. (B and C) Flow cytometry was performed to detect the apoptotic rate of LNCaP cells. (D) Migration assay of LNCaP cells transfected with miR-NC, anti-miR-381 or miR-381 mimics. (E) Invasion assay of LNCaP cells transfected with miR-NC, anti-miR-381 or miR-381 mimics. *P<0.05, **P<0.01, ***P<0.001 compared with miR-NC. FITC, fluorescein isothiocyanate; miR, microRNA; NC, negative control; OD, optical density; PI, propidium iodide.