Table 1.

Parameters in cell model, with nominal values and derivation of value.

Current	Parameter	Nominal value	Derivation
INa	gNa	12 mS/μF	Chosen so conduction velocity in 1D monodomain simulations was 60 cm/s (Kadish et al., 1986) – see text
	Em	−52.244 mV	$m_{\infty }^3(V)$ fit to voltage clamp data (Cordeiro et al., 2008, Figure 5D) (canine epicardial data, averaged over cells)
	km	6.5472 mV
	${\tau }_m^{*}$	0.12 ms	Taken from Gray and Pathmanathan (2016) (based on rabbit INa activation data under physiological conditions, due to lack of canine INa activation data under physiological conditions). Together with δh, τh0 and some IKr parameters, these are the only parameters based on non-canine data.
	Eh	−78.7 mV	Taken from Pathmanathan et al. (2015) (Table 1), which is derived from fits to canine epicardial data published in Cordeiro et al. (2008).
	kh	5.93 mV
	δh	0.799163	Taken from Gray and Pathmanathan (2016). Together with ${\tau }_m^{*}$ and some IKr parameters these are the only parameters based on non-canine data.
	τh0	6.80738 mV
IK1	gK1	0.73893 mS/μF	All derived by simultaneously fitting the IK1 model to canine epicardial voltage clamp recordings (unpublished). Experimental EK was also fit as a free parameter, and Ez was shifted to correspond to EK = −85mV
	Ez	−91.9655 mV
	kz	12.4997 mV
Ito	gto	0.1688 mS/μF	Derived by fitting the Ito model with s = 1 to Ito activation voltage clamp recordings [raw data behind Figure 2 of Cordeiro et al. (2012)].
	Er	14.3116 mV
	kr	11.462 mV
	Es	−47.9286 mV	Derived by fitting s∞(V) to Ito inactivation voltage clamp recordings [raw data behind Figure 3 of Cordeiro et al. (2012)].
	ks	4.9314 mV
	${\tau }_s^{*}$	9.90669 ms	Average of τs(V) for voltages in range 10-50 mV using raw data behind Figure 2 of Cordeiro et al. (2012).
ICaL	gCaL	0.11503 mS/μF	Derived by fitting the ICaL model to data digitized from Iyer et al. (2012) (Figure 3, epi) using values of Ed, kd, Ef, kf below
	Ed	0.7 mV	Taken from Table 2 in Iyer et al. (2012)
	kd	4.3 mV
	Ef	−15.7 mV
	kf	4.6 mV
	${\tau }_f^{*}$	30 ms	Taken from Xiao et al. (2006) (Figure 8)
IKr	gKr	0.056 mS/μF	gKr, gKs and ${\tau }_{xr}^{*}$ were jointly calibrated so simulated APD restitution matched experiment – see text
	Exr	−26.6 mV	Taken from Berecki et al. (2005) (Table 1), based on HEK cell data.
	kxr	6.5 mV
	${\tau }_{xr}^{*}$	334 ms	gKr, gKs and ${\tau }_{xr}^{*}$ were jointly calibrated so simulated APD restitution matched experiment – see text
	Ey	-49.6 mV	Taken from Berecki et al. (2005) (Table 1), based on HEK cell data.
	ky	23.5 mV
IKs	gKs	0.0080 mS/μF	gKr, gKs and ${\tau }_{xr}^{*}$ were jointly calibrated so simulated APD restitution matched experiment – see text
	Exs	24.6 mV	Taken from Liu and Antzelevitch (1995) (text).
	kxs	12.1 mV
	${\tau }_{xs}^{*}$	628 ms
Other	ENa	65 mV	Taken from Gray and Pathmanathan (2016).
	EK	−85 mV	Based on resting membrane potential recordings in Di Diego et al. (1996)
	ECa	50 mV	Based on data digitized from Iyer et al. (2012) (Figure 3, epi)