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. 2019 May 27;44:150–161. doi: 10.1016/j.ebiom.2019.05.046

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Suppression of FOX-A1 enhances the in vivo chemosensitivity of docetaxel-resistant LAD cells to DTX. a, Tumor growth was assessed by the tumor volume in nude mice that were subcutaneously transplanted with sh-control (or sh-FOX-A1#1)-transfected SPC-A1/DTX cells combined with DTX treatment. The data are displayed as means±standard deviation. Representative photographs of tumors are provided at 30 days after inoculation. b-c, Tumor volume and weight of xenograft tumors at the end of the treatment period. ^⁎⁎P < 0.01. d, H&E staining, immunohistochemical staining of FOX-A1, proliferating cell nuclear antigen (PCNA) and Ki67 staining and TUNEL staining were performed using tumors collected at 30 days after inoculation. Scar bar: 50 μm. e-f, The positive rate of PCNA and Ki67 expression in tumors developed from sh-control (or sh-FOX-A1#1)-transfected SPC-A1/DTX cells combined with DTX treatment. ^⁎⁎P < 0.01. g, The level of E-cadherin, N-cadherin and Vimentin in sh-FOX-A1#1 group and sh-control group. h, Kaplan-Meier analysis of the OS of nude mice that were subcutaneously transplanted with sh-control (or sh-FOX-A1#1)-transfected SPC-A1/DTX cells combined with DTX treatment.^⁎⁎P < 0.01. Data are presented as means±standard deviation.