Supplementary Fig. 3.

SOX5 is involved in the chemoresistance of docetaxel-resistant LAD cells in vivo. a, Tumor growth was assessed by the tumor volume in nude mice subcutaneously transplanted with sh-control (or sh-SOX5#3)-transfected SPC-A1/DTX cells combined with DTX treatment. The data are displayed as means±standard deviation. Representative photographs of tumors were obtained at 30 days after inoculation. b-c, Tumor volume and weight of xenograft tumors at the end of the treatment period. ^⁎⁎P < .01. d, H&E staining, PCNA and Ki67 staining and TUNEL staining were performed with tumors collected at 30 days after inoculation. Scar bar, 50 μm. e-f, The positive rate of PCNA and Ki67 expression in tumors that had developed from sh-control (or sh-SOX5#3)-transfected SPC-A1/DTX cells combined with DTX treatment. g, The level of E-cadherin, N-cadherin and Vimentin in sh-SOX5#3 group and sh-control group. h, Kaplan-Meier analysis of the OS of nude mice subcutaneously transplanted with sh-control (or sh-SOX5#3)-transfected SPC-A1/DTX cells combined with DTX treatment. ^⁎⁎P < .01. Data are presented as means±standard deviation.