a, Resistance of SPC-A1/DTX or H1299/DTX cells to cisplatin or paclitaxel was determined after silencing of FOX-A1. ⁎P < .05. b, FOX-A1 expression in normal cell line or ten NSCLC cell lines. ⁎P < .05, ⁎⁎P < .01. c, Sensitivity of eight NSCLC cell lines to docetaxel was examined after overexpression of FOX-A1. ⁎P < .05, ⁎⁎P < .01. d, Body weight of nude mice injected with different cell lines. ⁎P < .05. e, FOX-A1 or SOX5 expression in docetaxel-resistant LAD cell lines transfected with miR-NC or miR-451 mimics. MiR-451 expression in FOX-A1 or SOX5-downregulated cell lines. N·S: no significance. Data are presented as means±standard deviation.