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. 2019 May 27;18(2):1402–1408. doi: 10.3892/ol.2019.10398

Figure 4.

Figure 4.

Relative protein expression of Bax, Bcl-2 and MMP-9. CRC cells were divided into four different groups: Empty vector group, PDCD4 overexpression group, Taxol treatment group, and Taxol treatment + PDCD4 overexpression group. At 48 h post-treatment, total cell lysates were assayed via western blotting with the indicated antibodies. GAPDH was used as the loading control. Compared with the empty vector group, Bax protein level in the PDCD4 overexpression and Taxol treatment groups were significantly increased, which was further induced by co-administration of Taxol and the PDCD4 plasmid. Bcl-2 and MMP-9 protein levels were significantly decreased in the PDCD4 overexpression and Taxol groups, and enhanced by co-administration of Taxol and the PDCD4 plasmid. Data are presented as the means ± SD. *P<0.05, **P<0.01. PDCS4, programmed cell death factor 4; CRC, colorectal cancer; Bcl-2, B-cell lymphoma-2; BAX, Bcl-2-associated X protein; MMP-9, matrix metalloproteinase-9.