Table III.
Univariate and multivariate Cox regression analyses of miR-125b expression, clinicopathological features and overall survival.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Clinicopathological feature | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Sex | 0.979 | |||
| Male | Reference | |||
| Female | 1.013 (0.390–2.628) | |||
| Age, years | 0.080 | |||
| <60 | Reference | |||
| ≥60 | 2.471 (0.898–6.797) | |||
| Tumor diameter, cm | 0.124 | |||
| <2 | Reference | |||
| ≥2 | 2.116 (0.814–5.501) | |||
| Lymph node metastasis | 0.012 | 0.266 | ||
| No | Reference | |||
| Yes | 3.822 (1.339–10.912) | |||
| TNM stage | 0.053 | |||
| I/II | Reference | |||
| III/IV | 2.703 (0.985–7.413) | |||
| Lesion location | 0.041 | 0.185 | ||
| Non-acral | Reference | |||
| Acral | 0.364 (0.138–0.960) | |||
| miR-125b expression | 0.010 | 0.011 | ||
| Low expression | Reference | Reference | ||
| High expression | 0.243 (0.084–0.707) | 0.252 (0.087–0.729) | ||
HR, hazard ratio; CI, confidence interval; miR-125b, microRNA-125b.