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. 2019 May 27;18(2):1278–1286. doi: 10.3892/ol.2019.10400

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Copyright: © Tan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — DNA hypermethylation is identified in the PTTG1IP promoter region. The location on chromosome 21, the distribution of the CpG islands and CpG sites in the PTTG1IP promoter are listed in the top half of the figure. The DNA methylation levels in tumors and adjacent tissues based on reduced representation bisulfite sequencing analysis are presented in grayscale. Darker colors indicate higher levels of methylation. PTTG1IP, pituitary tumor transforming gene 1 binding factor; TSS, transcription start site.