Table II.
Differentially expressed genes associated with the cell cycle in Raji cells followingPVT1 knockdown.
| Gene symbol | Accession no. | Gene description | Fold change |
|---|---|---|---|
| CCNG2 | NM_004354 | Cyclin G2 | 7.03 |
| RBL2 | NM_005611 | Retinoblastoma-like 2 (p130) | 5.26 |
| CDKN1A | NM_000389 | Cyclin-dependent kinase inhibitor 1A (P21, Cip1) | 4.78 |
| CCNT1 | NM_001240 | Cyclin T1 | 4.17 |
| CASP3 | NM_004346 | Caspase 3, apoptosis-related cysteine peptidase | 3.96 |
| RBL1 | NM_002895 | Retinoblastoma-like 1 (p107) | 3.70 |
| RB1 | NM_000321 | Retinoblastoma 1 | 3.68 |
| HUS1 | NM_004507 | HUS1 checkpoint homolog (S. pombe) | 3.38 |
| CCND2 | NM_001759 | Cyclin D2 | 2.51 |
| CDC6 | NM_001254 | Cell division cycle 6 homolog (S. cerevisiae) | 2.34 |
| CDKN1B | NM_004064 | Cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 2.31 |
| TFDP2 | NM_006286 | Transcription factor Dp-2 (E2F dimerization partner 2) | 2.23 |
| CDC16 | NM_003903 | Cell division cycle 16 homolog (S. cerevisiae) | 2.21 |
| GADD45A | NM_001924 | Growth arrest and DNA-damage-inducible, alpha | 2.08 |
| CDKN3 | NM_005192 | Cyclin-dependent kinase inhibitor 3 | 2.07 |
| ABL1 | NM_005157 | C-abl oncogene 1, non-receptor tyrosine kinase | 2.04 |
| BRCA2 | NM_000059 | Breast cancer 2, early onset | −2.22 |
| CCNE1 | NM_001238 | Cyclin E1 | −2.05 |
| CCND1 | NM_053056 | Cyclin D1 | −1.98 |
| CDK6 | NM_001259 | Cyclin-dependent kinase 6 | −1.85 |
| CDC20 | NM_001255 | Cell division cycle 20 homolog (S. cerevisiae) | −1.81 |
| ATM | NM_000051 | Ataxia telangiectasia mutated | −1.67 |
| CKS2 | NM_001827 | CDC28 protein kinase regulatory subunit 2 | −1.56 |
| CDK4 | NM_000075 | Cyclin-dependent kinase 4 | −1.52 |
Positive and negative values represent upregulation or downregulation of genes in the LV-PVT1-shRNA group compared with the LV-NC-shRNA group, respectively.