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A 5 year old male with ADEM. Multifocal and asymmetric hyperintensities on FLAIR (A) have only very minimal reduced (and mostly elevated) diffusion (arrows) on DWI (B) and ADC map (C), and multifocal enhancement (arrows) on post-contrast T1WI (D). After 6 weeks, the hyperintensities have mostly regressed on FLAIR (E), and there is resolution of enhancement on postcontrast T1-WI (F). The multifocal contrast enhancement is not typical for ATL.
