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A 62 year old immunocompromised male, with PML, has “T2-shine through” (i.e. highly elevated diffusion) on DWI (A) and elevated diffusivity on ADC map (B); typically asymmetric lesions of PML are also seen (arrows) on FLAIR (C). Such multifocal lesions usually have an incomplete rim of enhancement (arrows) on postcontrast T1WI, suggestive for PML-IRIS (D).
