Figure 2.

Effects of carboxamide derivatives and TMZ as inducers of apoptosis and oxidative damage in U251 cells. (A) Flow cytometry revealed that carboxamide derivatives (N2 and S2) and TMZ induced the apoptosis of U251 cells. NAC reduced the apoptosis induced by these compounds. (B) Fluorescence assay demonstrated that the carboxamide derivatives and TMZ induced the oxidative damage of U251 cells and NAC reversed the oxidative activity of the compounds. *P<0.05 vs. 0 µM. NAC, N-Acetyl-L-cysteine; TMZ, temozolomide.