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Composition of the different prototypes developed in this work. Schematic representation of the preparation process for the three developed nanosystems. (A) CS/DS + PCS5 NPs, (B) CS–PCS5/DS/pIC NPs, and (C) CS/HA–PCS5/pIC NPs. Key: CS, chitosan; DS, dextran sulfate; PCS5, protease cleavage site 5; NPs, nanoparticles; pIC, poly(I:C) (polyinosinic:polycytidylic acid); HA, hyaluronic acid.
